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The original SunTag platform, designed for up to ~300-fold transcriptional activation by recruiting multiple VP64 copies to a single-chain fragment variant (scFv) that binds GCN4, was modified by replacing VP64 with JARID1A to enable locus-specific demethylation
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Patients with Graves disease treated with methimazole showed mRNA expression levels of antioxidant enzymes similar to those of healthy subjects (Fig
doi: 10.1016/j.freeradbiomed.2018.03.016
