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While fluoroquinolones are lifesaving for certain infections, they should be used with caution, especially in high-risk groups like the elderly or those with kidney disease

In addition, (iv) the isocitrate dehydrogenases IDH1 and IDH2, which are located in the cytosol and mitochondria, respectively, are involved in NADPH production, and (v) glutamine metabolism is involved in NADPH generation through the glutamate dehydrogenases GDH1 and GDH2 in mitochondria

Cancer 119(10):1768-1775, 2013

The Xc complex (also known as System Xc), a glutamate-cystine antiporter composed of solute carrier family 3 member 2 and solute carrier family 7 member 11 (SLC7A11), is responsible for importing cystine into cells, which is then reduced to cysteine