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Down-regulation of hippocampal DA receptors may disinhibit thalamocortical pathways, thereby potentiating cortical hyperexcitability and increasing the likelihood of seizure occurrence 41

By inhibiting NNMT, 5-Amino-1MQ helps regulate energy metabolism, reduce fat storage, and enhance NAD+ levels, which are crucial for cellular energy production

Many of these pathways require adequate NAD+ levels for optimal function, meaning NAD+ restoration before treatment could be a strategy to ensure the underlying cells are in an optimal condition to respond to the treatment
