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Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151

PD-MCI in the posterior cingulate cortex exhibited reduced N-acetyl aspartate (NAA), total NAA, choline, glutathione, glutamate + glutamine, and total creatine (tCr) levels but both elevated myo-inositol (Ins) and Ins/tCr ratio, but reduced NAA/Ins ratio

It is important to note, however, that patients in the duloxetine group reported more moderate-intensity adverse effects (fatigue, somnolence, insomnia) compared to those in the placebo group, which resulted in a higher dropout rate (11% vs

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