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After euthanasia, the pancreas was perfused via the common bile duct with 24 mL of digestion buffer (Hanks Balanced Salt Solution containing type IV collagenase, 1 mg/mL, Gibco, 17104019)

This synthetic peptide based on a natural compound in stomach juice is stable in the stomach acid and can be effective when taken orally in studies

Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

Impulsivity and the inability to pay attention both improve dramatically [62]