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In ovarian cancer, MFAP2 promotes malignancy by activating the FOXM1/-catenin signaling axis, thereby enhancing aerobic glycolysis (the Warburg effect) [23]

Both oxidative damage to cells and reduced antioxidant capacity contribute to this disease

Safety, Tolerability, and Regulatory Perspective Multiple non-clinical toxicology programs and clinical studies have evaluated the safety of AOD 9604: A comprehensive non-clinical dossier reported no evidence of genotoxicity or major toxicological concerns across a range of pharmacokinetic and toxicity studies, supporting a favorable safety profile in standard preclinical models

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