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[DOI] [PubMed] [Google Scholar] 18.Haemmerle G, Zimmermann R, Strauss JG, Kratky D, Riederer M, Knipping G, et al

Methyl-B12 and methylfolate are often taken together because they work synergistically in the methylation cycle
The process typically begins within hours of administration and can remain active for 12-24 hours based on the sustained activation of lipolytic enzymes and metabolic pathways

Of course, its best to avoid damage to the nerves in the first place by following your doctors advice and making changes to your lifestyle that keep your blood sugars at the recommended levels
