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Description
5-amino-1MQ showed concentration-dependent inhibition of NNMT in fully differentiated adipocytes that could be fit to a 3-parameter sigmoidal dose-response curve with a calculated EC 50 = 2.3 +/ 1.1 M (Figures 2E, 2F
The analogue 5-amino-1MQ was tested at concentrations from 600 M 30 nM
Overexpression of NNMT has been linked to obesity, insulin resistance, and impaired NAD metabolism
Harley, I
