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Animal studies examining cartilage integrity have noted potential improvements in matrix composition and joint flexibility during recovery periods, making it a research candidate in post-injury musculoskeletal models
An association with vitamin B 12 deficiency in non-metformin-exposed individuals and genotype was also demonstrated for both AG (OR 1.11 [95% CI 0.99, 1.24], I 2 =19.3%) and AA (OR 1.42 [95% CI 1.21, 1.67], I 2 =14.4%) genotypes but ORs were lower than in metformin-exposed individuals
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