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Numerous clinical studies have demonstrated that IGF-1/IGF-1R mutations are associated with mental retardation and microcephaly [34, 35] (Table 2)

In a validated operant mouse model of tinnitus, transient administration of RL-81 1 week after acoustic trauma mitigated the development of behavioral evidence of tinnitus, without affecting the underlying hearing loss (Marinos et al., 2021)

Additionally, the toxic compound MG is detoxified through the coordinated action of glyoxalase (Gly I and II) [11]

TLR4-knockout mice maintained regular estrous cycling, exhibited normalized luteinizing hormone and follicle-stimulating hormone levels, and showed reduced weight gain and improved glucose tolerance compared with wild-type controls (Dominique Wiggins et al., 2023)