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In rodents, iron supplementation (200mg Fe/kg food/d) lowered the omega-6 and omega-3 PUFA concentrations, raised the omega-6:omega3 ratios, and decreased hepatic and adjacent extrahepatic FA unsaturation and 5 and 6 desaturase activity [90]
Kim DS, Jung SJ, Nam TS, et al

Qu, W., Pi, J