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Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

Interestingly, loss of intracellular hydrogen peroxide or lipid hydroperoxides by overexpression of catalase or GPx-4, respectively, inhibits cell cycle progression from G 0 /G 1 - to S-phase (278, 377)

Sepulveda AR, Hamilton SR, Allegra CJ, Grody W, Cushman-Vokoun AM, Funkhouser WK, Kopetz SE , Lieu C, Lindor NM, Minsky BD, Monzon FA, Sargent DJ, Singh VM, Willis J, Clark J, Colasacco C, Rumble RB, Temple-Smolkin R, Ventura CB, Nowak JA

In the group with CLP-induced sepsis, there was a substantial decrease in CAT activity, indicating a significant impact of sepsis on antioxidant enzyme levels, compared to the control group