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Activation of the SIRT1/Nrf2 pathway, such as by alpha lipoic acid, can modulate iron metabolism and mitigate ferroptosis by up-regulating ferritin and ferritin heavy chain 1 (FTH1), and down-regulating the iron import protein divalent metal transporter 1 (DMT1) (Zheng et al., 2023)

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When using longer-term biomarkers such as AF-Alb/AFB1-Lys, the reported transfer is based on assuming exposure occurring repetitively on a daily basis ahead of the measurement

NTZ, especially at the higher dose, elicited similar hepatoprotective effects comparable to NAC and 4-PBA, indicating the possible involvement of ER stress modulation in NTZ-elicited hepatoprotective effects