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Mitophagy can be inhibited with 3-methyladenine (3-MA) resulting in macrophage polarization towards the M1 phenotype, while the induction of mitophagy with rapamycin can enhance the M2 phenotype in macrophages by inhibiting the production of mtROS and NLRP3 inflammasome activation (154, 155)

5-Amino-1MQ is studied in laboratory models involving NNMT pathway behavior, NAD-associated metabolism, cellular energy signaling, adipocyte-associated pathway activity, nutrient-response biology, and metabolic regulation

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