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Following studies in rats showed that this seems to be not mediated by the adrenal gland, but rather mediated by the descending vagal pathway following central MC4R activation ( The remarkable effects of the melanocortin system in regulating cardiovascular function, however, have been long standing obstacle to the use of melanocortin system-modulating compounds for the treatment of other conditions such as obesity, without affecting HR and BP

doi:10.1038/jcbfm.2009.112 Urrutia A, Rubio-Araiz A, Gutierrez-Lopez MD, ElAli A, Hermann DM, OShea E, Colado MI (2013) A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine