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P53 directly increases GH production, endocrine GH promotes the expression of ATM through JAK2-activated TRIM29, and next regulates HR pathway to repair DNA damage (Sho et al., 2011)

The phosphatidylinositol 4-kinase alpha (PI4KA) inhibitor cefadroxil (CEP) destabilizes the PI4KA/tetratricopeptide repeat domain 7 (TTC7)/family with sequence similarity 126 (FAM126) complex and inhibits ATP production by modulating the extracellular signal-regulated kinase (ERK)/adenosine monophosphate-activated protein kinase (AMPK)/OXPHOS axis, thus enhancing chemotherapeutic drug resistance in drug-resistant leukemia cells in vitro and in vivo, thereby providing a new therapeutic strategy for the treatment of refractory leukemia (Jiang 2022)

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