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When P-15 is added in scaffold material, it results in a significantly higher gene expression of alkaline phosphatase (ALP), BMP-2 and BMP-7 [235]

It seems that persistent NRF2 activation increases anti-oxidant and detoxification capacities at the expense of juvenescence

Structural variability among oligomers is substantial and plays a critical role in determining their toxic potential, as different conformational states can exert distinct effects on cellular homeostasis [51, 88, 158, 200, 223]

It has been demonstrated that the administration of Astragalus can prevent cellular aging, owing to its diverse range of actions that provide protection to the body from both external and internal factors