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doi: 10.1016/s0016-5085(99)70551-2
Detoxification of arsenite, thiol-reactive heavy metals, and xenobiotics requires conjugation with GSH or its oligomers phytochelatins [139,140] and consequently results in the fast depletion of cytosolic GSH
Phospholipids, particularly those enriched with polyunsaturated fatty acids (PUFAs) such as arachidonic acid, are highly susceptible to peroxidation in the plasma membrane
GSH depletion may play a central role in inflammatory diseases and COVID-19 pathophysiology, host immune response and disease severity and mortality
