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Another triterpenoid compound, omaveloxolone, has been approved by the FDA for the treatment of Friedreich's ataxia [464]

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The same group further reported significant increases in IL-17 from Th17 cells in mice with floxed Gpx4 alleles, suggesting that the proper homeostasis of GSH through Gpx4 specifically is relevant to the homeostasis of multiple T helper cell lineages

S2 MCDB131 (Corning, USA), 1% Glutamax (Thermo Fisher Scientific, Netherlands) + 1% Pen/Strep (Thermo Fisher Scientific, Netherlands), 4.44 mM glucose (Merck Millipore, USA), 14 mM sodium bicarbonate (Merck Millipore, USA) and 0.1% BSA (Capricorn Scientific, USA)