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The dysregulation of the opioid system in fibromyalgia is closely associated with a variety of neurobiological dysfunctions, including imbalances in major neurotransmitter systems, especially serotonin and noradrenaline [158]
Kratom-associated polyintoxications and in vitro-in vivo extrapolations suggest that kratom can precipitate pharmacokinetic drug interactions by inhibiting CYP2D6, CYP3A, and P-glycoprotein
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