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Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia

In the promotion stage, these mutated cells rapidly multiply due to increased cell growth or reduced apoptosis, with oxidative stress playing a key role by temporarily affecting genes that regulate cell division and death

Therefore, inhibiting ferroptosis represents a potential strategy to augment HSC numbers, supporting the production of all blood cell types, including red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes)

However, induction of MMP by anti-TNF treatment has also been reported, warranting further investigations [184]