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Glutathione transport in the endo/sarcoplasmic reticulum

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However, it differs from other forms of PCD in that ferroptosis is based on divalent iron and leads to cell death by promoting lethal accumulation of intracellular lipid peroxides [12]

Another Phase III clinical trial involving 443 AML patients (NCT02993523) demonstrated that the combination of 5-Aza (75 mg/m 2 ) + Venetoclax (100 mg/200 mg/400 mg) was associated with high response rates, durable remissions, and significant improvements in OS among AML patients ineligible for standard chemotherapy [352,353,354,355]