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Battisti, M

It also modulates systemic mineral balance by suppressing parathyroid hormone (PTH) and fine-tuning the FGF23Klotho signaling axis (41, 42), thus preserving calciumphosphate homeostasis and bonekidney axis integrity

The pathophysiological mechanism activates local inflammation, which is a barrier to allograft long-term immune tolerance

Therapeutic doses of vitamin C may act against cancer development and progression through several other mechanisms, such as stimulating immune system activation or enhancing the chemosensitivity of cancer cells, but evidence beyond preclinical models is still lacking (124, 125)