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For indoxyl sulfate and hippuric acid measurements, each sample (1 L) was injected into 100 2.0 mm CAPCELL PAK C18 MG III, 3-m column (OOSAKA SODA, Osaka, Japan) with Scherzo SM-C18 guard column 5 2.0 mm (Imtakt Corporation, Kyoto, Japan) at a flow rate of 0.2 mL/min

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Recently, a highly specific transporter for ET (ETT) was identified in mammalian tissues, which explains abundant tissue levels of ET and implies a physiologic role