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However, in the 1980s this hypothesis was changed by the identification of IGF-I production in numerous tissues (Figure 6)

Lutz, S

M.AnsariS

Konopka et al., 2020), cytoplasmic mislocalization of nuclear proteins (Neumann et al., 2006), mitochondrial dysfunction (Albers and Beal, 2000), glutamate excitotoxicity (Shaw and Ince, 1997), proteasomal and autophagic dysfunction (Chen et al., 2012), ER stress (Nagata et al., 2007
