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Description
In the formation of TLS, because an enormous number of immune cells are ectopically recruited to nonlymphoid organs, it is speculated that dramatic metabolic remodeling occurs in immune cells in the organ

Moreover, for patients resistant to MET inhibitors, the potential of PD-1/PD-L1 inhibitors to reverse or ameliorate resistance is an area ripe for exploration

This suggests either that transcriptional control of these types of proteins is not an important part of the response or that accumulation of GSSG is not in itself sufficient to induce significant protein S -glutathionylation

[DOI] [PubMed] [Google Scholar] 88.Steenvoorden D.P., Van Henegouwen G.M
