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The R 2 of all the mathematical models is high in the range of 0.900.99, indicating that the data is order kinetics

10.1016/j.jep.2018.05.019 [DOI] [PubMed] [Google Scholar] 51.Caporali S, De Stefano A, Calabrese C, Giovannelli A, Pieri M, Savini I, et al

However, the concentrations of both allopurinol and oxypurinol achieved during in vivo pharmacotherapy seem to be too low for their antioxidant effect (if there is any) to be of therapeutic importance (Halliwell and Gutteridge, 2015)

In particular, upon administration in mice, only the mono-glutathionylated adducts were not toxic to kidneys, while a correlation was recorded between the number of glutathione substitutions and the nephrotoxicity observed [83]