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The International Scientific Association for Probiotics and Prebiotics defined probiotic calibration in 2013 as providing a health benefit to the host when administered in sufficient numbers of living microorganisms, which includes microorganisms that have been shown to have a health benefit in controlled trials and new symbiotic strains from human samples (127)

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Disease burden of Parkinson's disease in Asia and its 34 countries and territories from 1990 to 2021: findings from the Global Burden of Disease Study 2021

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