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Even with severe caval/portal hypertension, BPC 157 antagonized portal and caval hypertension and aortal hypotension
Mechanistically, hyperglycemia enhances M1 macrophage polarization through the miR-32/Mef2d/cAMP pathway, directly upregulating pro-inflammatory genes while downregulating autophagy markers, creating a autophagic defect-inflammatory amplification loop (59)
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