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10.1016/j.tins.2013.10.003 227

The oxidative stress in mitochondria could be counteracted by IDH1-driven reductive carboxylation in the cytosol, followed by the transfer of citrate into the mitochondria, which was to be oxidized by IDH2 to generate NADPH [104]

Moreover, SLC7A5 inhibitors could also be used for the treatment of patients with NSCLC without EGFR mutations (93)
