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Denno P, Zhao S, Husain M, Hampshire A

The ROS generated through radiolysis of cellular water and the free iron take part in the Fenton reaction-mediated lipid peroxidation of the plasma membrane and finally cell death through ferroptosis (Fig

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The activation of major histocompatibility complex (MHC) Class II-dependent T-cells by citrullinated neoantigens promotes B-cells production of more ACPAs and the activation of inflammatory mediators like TNF-, IL-1, IL-6, and NF-B, leading to pannus formationa thickened synovial layer that invades and destroys cartilage and bone