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Meier, Zurich (Mdecine interne)
RSL3, a ferroptosis inducer, directly acts on GPX4 and inhibits its activity, thus reducing the antioxidant capacity of cells and accumulating ROS, leading to ferroptosis 12
The FSP1-CoQ10-NADPH pathway could cooperate with GSH and GPX4 to scavenge lipid peroxidation intermediates [49, 50]
Together, they are thought to produce synergistic GH output greater than either compound alone
