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This is normally the case but doesnt always happen perfectly
PMID: 27 XiaoY.GuoQ.XieN.YuanG.LiaoM.GuiQ.et al
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The polyol pathway leads to the conversion of glucose to sorbitol and further to fructose, thus reducing the availability of cofactors such as NADPH needed for the glutathione peroxidaseglutathione reductase system, rendering the cell more vulnerable to reactive oxygen species (ROS), and therefore reinforcing oxidative stress [39][40]
