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Failures arent always linear or predictable, and tools alone dont guarantee early detection,execution, culture, and people competency matter just as much as technology

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Cigarette smoke can reduce the expression of Frizzled receptor 4 (FZD4) in alveolar epithelial cells and enhance the phosphorylation of -catenin, inhibiting epithelial proliferation and alveolar repair mediated by the classic Wnt signalling pathway
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