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Also known as Cobalamin, Vitamin B12 is a water-soluble vitamin and one of eight essential B vitamins, which plays a crucial role in numerous bodily functions, such as: Supporting energy production Aiding nervous system functionality Enhancing mood and cognitive function Facilitating the formation of red blood cells in bone marrow Promoting healthy skin, nails, and mucous membranes Supporting bone and glandular health Boosting immune and digestive systems Assisting with fertility and healthy pregnancies Vitamin B12 Deficiency: Signs & Symptoms Vitamin B12 deficiency often stems from dietary restrictions, such as vegetarian or vegan diets, poor absorption caused by disorders like Crohns Disease, or the effects of certain medications, including Metformin and Nitrous Oxide

Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243