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GSH is found in almost all bacterial, plant, and mammalian cells in high concentration, typically 0.512 mmol l 1 (Stevens and Jones, 1989, Taniguchi et al., 1989)

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This observation may be explained by the fact that -ketoglutarate (KG), a product of glutaminolysis, is required for ferroptosis (Gao et al., 2015)

In high-grade astrocytoma (WHO IV grade), or glioblastoma (formerly glioblastoma multiforme), hemorrhage and necrosis are expected, and the adventitial and endothelial cells of the vessels proliferate, forming glomeruloid blood vessels