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Overall, the position of different mutations can affect protein catalytic activity and stability to various degrees, with mutations in specific region of the protein leading to more severe deficiency
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doi: 10.1186/s12970-014-0066-3 [DOI] [PMC free article] [PubMed] [Google Scholar] [286].Szymanski MC, Gillum TL, Gould LM, et al
