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The degeneration of dopaminergic neurons can be induced by overexpression of DATs, which enhance DA re-uptake to increase cytosolic DA levels in PD models in vivo [51, 52]
Among other pathologies, impaired neurotransmission, autoimmune dysfunction, abnormal neuronal development, and oxidative stress have been proposed (Kessler 1997
Biochem Biophys Res Commun (2009) 390(3):80914
