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It is important to note that there is evidence for this AOP primarily in fish studies, however there is no indication that this AOP would not be applicable to other species or life stages

Preclinical and clinical development of siRNA-based therapeutics

Since then, no further serum/blood samples were found positive for this compound (Vidal et al

The presence of the D1236 (from MRP2 substitution) instead of G1228 (wild-type MRP1) in the chimera M8 could create a steric hindrance, as shown by the Cryo-EM apo and LTC 4 bound (inward-facing) structures of bovine MRP1 40,44 (Fig
