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Interestingly, several clock genes are expressed within the pituitary with a circadian rhythm independent of the SCN (75)
They found insufficient evidence to recommend dose reduction, a strategy viewed as a legitimate way to prevent TD during maintenance antipsychotic drug therapy
however, this form of InsP 7 makes minor contributions to the total InsP 7 levels in mammalian cells 3,4,5,6 , which suggests that IP6K-mediated 5-InsP 7 generation is the predominant InsP 7 pathway leading to InsP 8 (Fig
