n acetylcysteine glutathion Can N-acetylcysteine (NAC) Supplements Increase Cellular Glutathione Acemuk, N-Acetylcysteine Supplement, 600 mg,
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Reduced WM connectivities of the sensorimotor cortex have also been observed in HD and are related to motor, oculomotor, and cognitive symptoms (Dumas et al., 2012)

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Abbreviations ACOX1: Acyl coenzyme A oxidase 1 AIEgen: Aggregation induced emission luminogen ALI: Acute lung injury AOX1: Aldehyde oxidase 1 AQP: Aquaporins ARE: Antioxidant response element BAT: Brown adipose tissue BMAL1: Basic helix-loop-helix ARNT-like protein 1 BNIP1: BCL2 interacting protein 1 BNIP3: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BS: Brainstem C53: Cysteine 53 CAT: Catalase CB: Cerebellum CBS: Cystathionine-beta-synthase CLC3: Chloride channel-3 CoQ: Coenzyme Q CRY: Cryptochrome CYP450: Cytochrome P450 enzymes CytC: Cytochrome c CytoROS: Cytoplasmic ROS DAO: D-amino acid oxidase DDR: DNA damage response DRP1: Dynamin-related protein 1 DUOX1: Dual oxidase 1 DUOX2: Dual oxidase 2 EGF: Epidermal growth factor EMT: Epithelial-to-mesenchymal transition ER: Endoplasmic reticulum ERO1: Eukaryotic endoplasmic reticulum sulfhydryl oxidase 1 ETC: Electron transport chain EZH2: Enhancer of zeste homologue 2 FIS-1: Fission 1 GA: Golgi apparatus GOLPH3: Golgi phosphoprotein 3 GPR17: Guanine nucleotide binding protein coupled receptor 17 GPX: Glutathione peroxidase GSH: Glutathione GSR: Glutathione reductase GSSH: Glutathione disulfide HAO1: Hydroxyacid oxidase 1 HIF-1: Hypoxia-inducible factor 1 HSF1: Heat shock transcription factor 1 HYP: Hypothalamus KO: Knockout LV: Liver MAO: Monoamine oxidase MFF: Mitochondrial fission factor MFN1/2: Mitofusin 1/2 MMS: Mitochondrial misfolding stress MOF: Lysine acetyltransferase 8 MtROS: Mitochondrial reactive oxygen species NAMPT: Nicotinamide phosphoribosyltransferase NF-B: Nuclear factor kappa B NK cells: Natural killer cells NOX: NADPH oxidases NRF2: Nuclear factor erythroid 2-related factor 2 NROS: Nuclear ROS OPA1: Optic atrophy 1 PCECs: Primary colonic epithelial cells PDI: Protein disulfide isomerase PDIA3: Protein disulfide isomerase family A member 3 PER: Period PEX5: Peroxisomal biogenesis factor 5 PML-NBs: Promyelocytic leukemia nuclear bodies PPAR: Peroxisome proliferator-activated receptor PPP: Pentose phosphate pathway PPRE: Peroxisome proliferator response elements PRDX: Peroxiredoxin PSs: Photosensitizers PtdIns(4)P: Phosphatidylinositol 4-phosphate QSOX1: Quiescin-sulfhydryl oxidase 1 RBCs: Red blood cells RET: Reverse electron transfer R in : Input resistance ROS: Reactive oxygen species RRE: REV-ERB/ROR response element Sac1: Suppressor of actin 1 SAPs: Spontaneous action potentials SCN: Suprachiasmatic nucleus SDH: Succinate dehydrogenase SIRT1: Sirtuin 1 SLC25: Members of the mitochondrial carrier family SM: Skeletal muscle SODs: Superoxide dismutases SOD1: Cu/Zn superoxide dismutase SOD2: Manganese superoxide dismutase SQR: Succinate coenzyme Q reductase SUOX: Sulfite oxidase TLRs: Toll-like receptors TNF-: Tumor necrosis factor-alpha Trx: Thioredoxin TRX2: Thioredoxin-2 TRXR2: Thioredoxin reductase 2 TTFLs: Transcriptional-translational feedback loops TXNDC5: Thioredoxin domain-containing 5 UPRmt: Mitochondrial unfolded protein response UQCC3: Ubiquinol cytochrome C reductase complex assembly factor 3 VLCFAs: Very long-chain fatty acids V m : Resting membrane potential WAT: White adipose tissue WT: Wild-type ZT: Zeitgeber time References Patterson WB, Young ND, Holzhausen EA, Lurmann F, Liang D, Walker DI, et al
