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Although lumbar puncture is not mandatory in all cases, CSF analysis may show elevated gamma-aminobutyric acid levels (71) and oligoclonal bands (41)

The development of small molecule angiotensin IV analogs to treat Alzheimers and Parkinsons diseases

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

Furthermore, the immunohistochemistry analysis evaluated the protective effects of the Au-PX-PLGA on dopaminergic neurons in the striatum and tyrosine hydroxylase, which is an essential enzyme in dopamine synthesis, served as the biomarker for dopaminergic neuron integrity