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Over a larger dose range, the relationship between cell killing and dose is more complex and is described by three different components: an initial slope (D 1 ), a final slope (D o ), and the width of the shoulder (n, the extrapolation number) or Dq, the quasi-threshold dose (Fig

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The environment can also alter DNA methylation or histone modifications, regulating the expression of inflammatory genes and enhancing the innate immune response ( Figure 2 )

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