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Hyperglycemic state increases the production of di-lipoylglycerol (DAG) (Hayashi and Shirai, 2022), which is an endogenous activator of PKC

It catalyzes the esterification of long-chain polyunsaturated fatty acids (PUFAs, (e.g., arachidonic acid) into membrane phospholipids, making them substrates for peroxidation by enzymes like lipoxygenases (ALOXs) ( 2+ , is an essential catalyst for ferroptosis via the Fenton reaction

The vital organs showed no histological changes, except for the liver, which presented necrotic foci, apoptotic cells, and mononuclear infiltrate
