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When free radicals build up in the mitochondria, energy production slows down

Intriguingly, breast cancer cells metastasized to the brain are less sensitive to glucose deficiency (136), which may attribute to upregulation of glutamine and branched chain amino acid oxidation (143)

Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway

The expression difference of ferroptosis-related DEGs with prognostic significance in breast cancer and healthy breast tissue were analyzed through the Human Protein Atlas (HPA) database, which is an online tool (www.proteatlas.org) that displays immunohistochemistry results of protein expression patterns in cancer tissues, healthy tissues and different cell types