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When COMT is dirtyespecially slow COMTestrogen metabolism suffers, leading to PMS, fibroids, heavy periods, perimenopause struggles, and hormone-related mood swings
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"Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia"

Sudden increases in activity are one of the main triggers for recurrence
