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Electromyography (EMG) studies show that imbalanced or delayed muscle activation can result in greater strain on the ACL during dynamic movements
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Interestingly, although lipid peroxidation amplifies PARP-1 activation, inhibiting PARP-1 can significantly reduce lipid peroxidation and maintain mitochondrial integrity, underscoring the link between PARP-1 overactivation and oxidative damage in promoting parthanatos [142, 143]
