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Finally, 70 studies met the selection criteria for qualitative analysis (eTable 2 & 3 in the Supplement) and 47 studies for quantitative synthesis (eTable 4 in the Supplement and Fig

In experimental studies exploring the epigenetic effects of disrupted light-dark cycles, various types of epigenetic alterations (e.g., DNA methylation, histone modifications, and miRNA expression) have been observed across different animal models