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The injectable route does offer better bioavailability since it bypasses first-pass metabolism in the gut and liver, but the total weekly dose from a compounded tirzepatide injection remains well below what studies have used to demonstrate significant metabolic effects
doi: 10.1038/s41598-018-28477-9 [DOI] [PMC free article] [PubMed] [Google Scholar] 41
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While both compounds interact with GLP-1 and GIP pathways, Retatrutide additionally targets glucagon receptors
