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Increased oxidative stress causes modifications of all subcellular organelles, including oxidation of endoplasmic reticulum Ca 2+ -ATPase and contractile proteins (actin and myosin being the most important) resulting in contractile dysfunction (Steinberg 2013)

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Keywords: estrogen, glutathione, catalase, menstrual cycle Introduction Antioxidant defenses help to prevent free radical-mediated injury (1, 2)